Pediatric Non-Hodgkin Lymphoma Questions & Answers

Updated: Jun 14, 2018
  • Author: J Martin Johnston, MD; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Questions & Answers

Overview

What is pediatric non-Hodgkin lymphoma (NHL)?

What causes disease progression in pediatric non-Hodgkin lymphoma (NHL)?

How is pediatric non-Hodgkin lymphoma (NHL) differentiated from acute leukemia?

What causes pediatric non-Hodgkin lymphoma (NHL)?

What is the role of immunosuppression in the etiology of pediatric non-Hodgkin lymphoma (NHL)?

What are the risk factors for secondary non-Hodgkin lymphoma (NHL)?

What geographic factors increase the risk of pediatric non-Hodgkin lymphoma (NHL)?

What is the role of genetics in the etiology of pediatric non-Hodgkin lymphoma (NHL)?

What is the prevalence of pediatric non-Hodgkin lymphoma (NHL) in the US?

What is the global prevalence of pediatric non-Hodgkin lymphoma (NHL)?

What are the racial predilections of pediatric non-Hodgkin lymphoma (NHL)?

What are the sexual predilections of pediatric non-Hodgkin lymphoma (NHL)?

Which age groups are at highest risk for pediatric non-Hodgkin lymphoma (NHL)?

What is the prognosis of pediatric non-Hodgkin lymphoma (NHL)?

What is the prognosis of pediatric CNS lymphoma?

What is the prognosis of relapsed or refractory pediatric non-Hodgkin lymphoma (NHL)?

What are the possible complications of pediatric non-Hodgkin lymphoma (NHL)?

Presentation

Which clinical history findings are characteristic of pediatric non-Hodgkin lymphoma (NHL)?

What are the signs and symptoms of localized pediatric non-Hodgkin lymphoma (NHL)?

What are the signs and symptoms of large cell pediatric non-Hodgkin lymphoma (NHL)?

What are the signs and symptoms of CNS involvement in pediatric non-Hodgkin lymphoma (NHL)?

When is primary cutaneous involvement seen in pediatric non-Hodgkin lymphoma (NHL)?

Which physical findings are characteristic of pediatric non-Hodgkin lymphoma (NHL)?

DDX

Which conditions are included in the differential diagnoses of pediatric non-Hodgkin lymphoma (NHL)?

What are the differential diagnoses for Pediatric Non-Hodgkin Lymphoma?

Workup

What is the role of lumbar puncture in the workup of pediatric non-Hodgkin lymphoma (NHL)?

What is the role of blood tests in the workup of pediatric non-Hodgkin lymphoma (NHL)?

How is the risk of respiratory arrest mitigated when performing diagnostic procedures for suspected pediatric non-Hodgkin lymphoma (NHL)?

What is the role of lab tests in the workup of pediatric non-Hodgkin lymphoma (NHL)?

What is the role of chest radiography in the workup of pediatric non-Hodgkin lymphoma (NHL)?

What is the role of ultrasonography in the workup of pediatric non-Hodgkin lymphoma (NHL)?

What is the role of echocardiography in the workup of pediatric non-Hodgkin lymphoma (NHL)?

What is the role of CT scanning in the workup of pediatric non-Hodgkin lymphoma (NHL)?

What is the role of PET/CT scanning in the workup of pediatric non-Hodgkin lymphoma (NHL)?

What is the role of bone scans in the workup of pediatric non-Hodgkin lymphoma (NHL)?

What is the role of serologic analysis in the workup of pediatric non-Hodgkin lymphoma (NHL)?

When is HIV testing indicated in the workup of pediatric non-Hodgkin lymphoma (NHL)?

How is a histologic diagnosis of pediatric non-Hodgkin lymphoma (NHL) made?

What is the role of bone marrow aspiration in the diagnosis of pediatric non-Hodgkin lymphoma (NHL)?

Which histologic findings are characteristic of pediatric non-Hodgkin lymphoma (NHL)?

Which histologic findings are characteristic of lymphoblastic lymphoma?

Which histologic findings are characteristic of small noncleaved cell lymphoma?

Which histologic findings are characteristic of large cell lymphoma

How is pediatric non-Hodgkin lymphoma (NHL) staged?

Treatment

How is pediatric non-Hodgkin lymphoma (NHL) treated?

What is the role of antibiotics in the treatment of pediatric non-Hodgkin lymphoma (NHL)?

When is central venous access indicated in the treatment of pediatric non-Hodgkin lymphoma (NHL)?

How is rapid progression of pediatric non-Hodgkin lymphoma (NHL) prevented?

How is tumor lysis syndrome treated in pediatric non-Hodgkin lymphoma (NHL)?

How is pediatric lymphoblastic lymphoma treated?

What is the LSA2 L2 protocol for the treatment of pediatric lymphoblastic lymphoma?

What is the modified LSA2 L2 protocol for the treatment of pediatric lymphoblastic lymphoma?

What are the German Berlin, Frankfurt, Muenster (BFM) protocols for the treatment of pediatric lymphoblastic lymphoma?

What are the Children's Oncology Group protocols for the treatment of pediatric lymphoblastic lymphoma?

How is advanced-stage pediatric lymphoblastic lymphoma treated?

How is pediatric small noncleaved cell lymphoma treated?

What is the Cooperative Group protocol for the treatment of pediatric small noncleaved cell lymphoma?

How are pediatric B cell ? derived large cell lymphomas (LCLs) treated?

How are pediatric anaplastic (T-cell) LCLs treated?

What is the role of radiation therapy in the treatment of pediatric non-Hodgkin lymphoma (NHL)?

How is relapsed pediatric non-Hodgkin lymphoma (NHL) treated?

When is lymph node excision and dissection indicated in the treatment of pediatric non-Hodgkin lymphoma (NHL)?

When is consultation with an intensive care specialist indicated in the treatment of pediatric non-Hodgkin lymphoma (NHL)?

When is consultation with a radiation oncologist indicated in the treatment of pediatric non-Hodgkin lymphoma (NHL)?

When is consultation with a nephrologist indicated in the treatment of pediatric non-Hodgkin lymphoma (NHL)?

What is included in the long-term monitoring of pediatric non-Hodgkin lymphoma (NHL)?

Medications

Which medications are used in the treatment of pediatric non-Hodgkin lymphoma (NHL)?

Which medications in the drug class Uricosuric Agents are used in the treatment of Pediatric Non-Hodgkin Lymphoma?

Which medications in the drug class Estrogens/Progestins are used in the treatment of Pediatric Non-Hodgkin Lymphoma?

Which medications in the drug class Progestins are used in the treatment of Pediatric Non-Hodgkin Lymphoma?

Which medications in the drug class Histamine H2 Antagonists are used in the treatment of Pediatric Non-Hodgkin Lymphoma?

Which medications in the drug class Antiemetic Agents are used in the treatment of Pediatric Non-Hodgkin Lymphoma?

Which medications in the drug class Antifungals are used in the treatment of Pediatric Non-Hodgkin Lymphoma?

Which medications in the drug class Antibiotics, Other are used in the treatment of Pediatric Non-Hodgkin Lymphoma?

Which medications in the drug class Corticosteroids are used in the treatment of Pediatric Non-Hodgkin Lymphoma?

Which medications in the drug class PD-1/PD-L1 Inhibitors are used in the treatment of Pediatric Non-Hodgkin Lymphoma?

Which medications in the drug class Antineoplastics, Other are used in the treatment of Pediatric Non-Hodgkin Lymphoma?