Lymphoproliferative Disorders Follow-up

Updated: Dec 09, 2014
  • Author: Donna A Wall, MD; Chief Editor: Robert J Arceci, MD, PhD  more...
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Follow-up

Further Inpatient Care

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  • Follow-up care of a child with lymphoproliferative disorder (LPD) can range from simple (eg, watchful observation) to very complex (bone marrow transplantation).
  • Coordinate with a team of subspecialists familiar with immunodeficiency disorders and the management of potentially toxic drug therapy.
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Inpatient & Outpatient Medications

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  • Inpatient and outpatient drugs depend on the nature of the underlying immunodeficiency syndrome.
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Deterrence/Prevention

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  • The best preventive measure is to correct the underlying immunodeficiency syndrome.
  • Children who have had a bone marrow transplant with an immunocompetent graft are unlikely to develop problems with a lymphoproliferative disorder.
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Prognosis

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  • Lymphoproliferative disorders prognoses are determined by the prevalence of immunodeficiency in the patient.
  • Ordinarily, a favorable response in a relatively immunocompetent patient is a good prognostic factor for long-term survival. Lymphoproliferative disorders of low-grade histological features tend to remit with a reduction of immunosuppression, whereas higher-grade lymphoproliferative disorders require a more aggressive therapeutic approach and often require several cycles of CHOP therapy with close follow-up.
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