Pediatric Seminoma Differential Diagnoses

1. Fernandes ET, Etcubanas E, Rao BN, Kumar AP, Thompson EI, Jenkins JJ. Two decades of experience with testicular tumors in children at St Jude Children's Research Hospital. J Pediatr Surg. 1989 Jul. 24(7):677-81; discussion 682. [QxMD MEDLINE Link].

2. Oliver RT, Mason MD, Mead GM, et al. Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: a randomised trial. Lancet. 2005 Jul 23-29. 366(9482):293-300. [QxMD MEDLINE Link].

3. Thomas GM, Williams SD. Testis. Perez CA, ed. Principles and Practice of Radiation Oncology. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1997. 1695-715.

4. Hussey DH. The testicle. Cox JD, ed. Moss' Radiation Oncology - Rationale, Technique, Results. 7th ed. St. Louis, MO: Mosby-Year Book; 1994. 559-86.

5. Warde PR, Sturgeon JFG, Gospodarowicz MK. Testicular cancer. Gunderson LL, Tepper JE, eds. Clinical Radiation Oncology. 2000. 844-62.

6. Bosl GJ, Sheinfeld J, Bajorin DF. Cancer of the testis. Devita VT, ed. Cancer: Principles and Practice of Oncology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1997. 1397-425.

7. Johnson KJ, Poynter JN, Ross JA, et al. Pediatric germ cell tumors and maternal vitamin supplementation: a Childrens Oncology Group Study. Cancer Epidemiol Biomarkers Prev. October 2009. 18(10):2661-4. [QxMD MEDLINE Link]. [Full Text].

8. Bräuner EV, Lim YH, Koch T, et al. Endocrine disrupting chemicals and risk of testicular cancer: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2021 Nov 19. 106 (12):e4834-60. [QxMD MEDLINE Link]. [Full Text].

9. Abomelha M. Pediatric testicular cancer: Two decades of Saudi national data. Urol Ann. 2017 Oct-Dec. 9 (4):310-4. [QxMD MEDLINE Link]. [Full Text].

10. Walsh TJ, Davies BJ, Croughan MS, Carroll PR, Turek PJ. Racial differences among boys with testicular germ cell tumors in the United States. J Urol. 2008 May. 179(5):1961-5. [QxMD MEDLINE Link].

11. Frazier AL, Hale JP, Rodriguez-Galindo C, Dang H, Olson T, Murray MJ, et al. Revised risk classification for pediatric extracranial germ cell tumors based on 25 years of clinical trial data from the United Kingdom and United States. J Clin Oncol. 2015 Jan 10. 33 (2):195-201. [QxMD MEDLINE Link].

12. Jacobsen KD, Olsen DR, Fossa K, Fossa SD. External beam abdominal radiotherapy in patients with seminoma stage I: field type, testicular dose, and spermatogenesis. Int J Radiat Oncol Biol Phys. 1997 Apr 1. 38(1):95-102. [QxMD MEDLINE Link].

13. Bauman GS, Venkatesan VM, Ago CT, et al. Postoperative radiotherapy for Stage I/II seminoma: results for 212 patients. Int J Radiat Oncol Biol Phys. 1998 Sep 1. 42(2):313-7. [QxMD MEDLINE Link].

14. Weissbach L, Bussar-Maatz R, Mann K. The value of tumor markers in testicular seminomas. Results of a prospective multicenter study. Eur Urol. 1997. 32(1):16-22. [QxMD MEDLINE Link].

15. Nazeer T, Ro JY, Amato RJ, et al. Histologically pure seminoma with elevated alpha-fetoprotein: a clinicopathologic study of ten cases. Oncol Rep. 1998 Nov-Dec. 5(6):1425-9. [QxMD MEDLINE Link].

16. Foster RS, Nichols CR. Testicular cancer: what's new in staging, prognosis, and therapy. Oncology (Williston Park). 1999 Dec. 13(12):1689-94; discussion 1697-700, 1703. [QxMD MEDLINE Link].

17. American Joint Committee on Cancer. AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer-Verlag; 2010. 471-80.

18. Gordon W Jr, Siegmund K, Stanisic TH, et al. A study of reproductive function in patients with seminoma treated with radiotherapy and orchidectomy: (SWOG-8711). Southwest Oncology Group. Int J Radiat Oncol Biol Phys. 1997 Apr 1. 38(1):83-94. [QxMD MEDLINE Link].

19. DeSantis M, Albrecht W, Holtl W, Pont J. Impact of cytotoxic treatment on long-term fertility in patients with germ-cell cancer. Int J Cancer. 1999 Dec 10. 83(6):864-5. [QxMD MEDLINE Link].

20. Hallak J, Kolettis PN, Sekhon VS, Thomas AJ Jr, Agarwal A. Sperm cryopreservation in patients with testicular cancer. Urology. 1999 Nov. 54(5):894-9. [QxMD MEDLINE Link].

21. Kliesch S, Bergmann M, Hertle L, et al. Semen parameters and testicular pathology in men with testicular cancer and contralateral carcinoma in situ or bilateral testicular malignancies. Hum Reprod. 1997 Dec. 12(12):2830-5. [QxMD MEDLINE Link].

22. Zapzalka DM, Redmon JB, Pryor JL. A survey of oncologists regarding sperm cryopreservation and assisted reproductive techniques for male cancer patients. Cancer. 1999 Nov 1. 86(9):1812-7. [QxMD MEDLINE Link].

23. Warde P, Gospodarowicz MK, Panzarella T, et al. Stage I testicular seminoma: results of adjuvant irradiation and surveillance. J Clin Oncol. 1995 Sep. 13(9):2255-62. [QxMD MEDLINE Link].

24. Zagars GK, Babaian RJ. Stage I testicular seminoma: rationale for postorchiectomy radiation therapy. Int J Radiat Oncol Biol Phys. 1987 Feb. 13(2):155-62. [QxMD MEDLINE Link].

25. Zagars GK, Babaian RJ. The role of radiation in stage II testicular seminoma. Int J Radiat Oncol Biol Phys. 1987 Feb. 13(2):163-70. [QxMD MEDLINE Link].

26. Schmidberger H, Bamberg M, Meisner C, et al. Radiotherapy in stage IIA and IIB testicular seminoma with reduced portals: a prospective multicenter study. Int J Radiat Oncol Biol Phys. 1997 Sep 1. 39(2):321-6. [QxMD MEDLINE Link].

27. Kiricuta IC, Sauer J, Bohndorf W. Omission of the pelvic irradiation in stage I testicular seminoma: a study of postorchiectomy paraaortic radiotherapy. Int J Radiat Oncol Biol Phys. 1996 May 1. 35(2):293-8. [QxMD MEDLINE Link].

28. Fossa SD, Horwich A, Russell JM, et al. Optimal planning target volume for stage I testicular seminoma: A Medical Research Council randomized trial. Medical Research Council Testicular Tumor Working Group. J Clin Oncol. 1999 Apr. 17(4):1146. [QxMD MEDLINE Link].

29. Niazi TM, Souhami L, Sultanem K, et al. Long-term results of para-aortic irradiation for patients with stage I seminoma of the testis. Int J Radiat Oncol Biol Phys. 2005 Mar 1. 61(3):741-4. [QxMD MEDLINE Link].

30. Sultanem K, Souhami L, Benk V, et al. Para-aortic irradiation only appears to be adequate treatment for patients with Stage I seminoma of the testis. Int J Radiat Oncol Biol Phys. 1998 Jan 15. 40(2):455-9. [QxMD MEDLINE Link].

31. Martin JM, Panzarella T, Zwahlen DR, Chung P, Warde P. Evidence-based guidelines for following stage 1 seminoma. Cancer. 2007 Jun 1. 109(11):2248-56. [QxMD MEDLINE Link].

32. Fiveash J, Sandler HM. Controversies in the management of stage I seminoma. Oncology (Huntingt). 1998 Aug. 12(8):1203-12; discussion 1212-21. [QxMD MEDLINE Link].

33. Buchholz TA, Walden TL, Prestidge BR. Cost-effectiveness of posttreatment surveillance after radiation therapy for early stage seminoma. Cancer. 1998 Mar 15. 82(6):1126-33. [QxMD MEDLINE Link].

34. Reiter WJ, Brodowicz T, Alavi S, et al. Twelve-year experience with two courses of adjuvant single-agent carboplatin therapy for clinical stage I seminoma. J Clin Oncol. 2001 Jan 1. 19(1):101-4. [QxMD MEDLINE Link].

35. Oliver RT, Mead GM, Rustin GJ, et al. Randomized trial of carboplatin versus radiotherapy for stage I seminoma: mature results on relapse and contralateral testis cancer rates in MRC TE19/EORTC 30982 study (ISRCTN27163214). J Clin Oncol. 2011 Mar 10. 29(8):957-62. [QxMD MEDLINE Link].

36. Mead GM, Fossa SD, Oliver RT, et al. Randomized trials in 2466 patients with stage I seminoma: patterns of relapse and follow-up. J Natl Cancer Inst. 2011 Feb 2. 103(3):241-9. [QxMD MEDLINE Link].

37. Warde P, Gospodarowicz M, Panzarella T. Management of stage II seminoma. J Clin Oncol. 1998 Jan. 16(1):290-4. [QxMD MEDLINE Link].

38. Steele GS, Richie JP, Stewart AK, Menck HR. The National Cancer Data Base report on patterns of care for testicular carcinoma, 1985-1996. Cancer. 1999 Nov 15. 86(10):2171-83. [QxMD MEDLINE Link].

39. Garcia-del-Muro X, Maroto P, Guma J, et al. Chemotherapy as an alternative to radiotherapy in the treatment od stage IIA and IIB testicular seminoma: a Spanish Germ Cell Cancer Group Study. J Clin Oncol. Nov 20 2008. 26(33):5416-21. [QxMD MEDLINE Link].

40. Capelouto CC, Clark PE, Ransil BJ, Loughlin KR. A review of scrotal violation in testicular cancer: is adjuvant local therapy necessary?. J Urol. 1995 Mar. 153(3 Pt 2):981-5. [QxMD MEDLINE Link].

Arnold C Paulino, MD Professor of Radiation Oncology, Methodist Hospital and Weill-Cornell Medical College; Associate Professor of Pediatrics, Baylor College of Medicine

Arnold C Paulino, MD is a member of the following medical societies: Radiological Society of North America, Children's Oncology Group, American Society of Clinical Oncology, International Society of Paediatric Oncology, American Medical Association, American Radium Society, American Society for Radiation Oncology

Disclosure: Received royalty from Elsevier, Inc for author of book.

Jodi Muscal, MD Assistant Professor of Pediatrics, Division of Hematology-Oncology, Baylor College of Medicine, Texas Children's Hospital

Jodi Muscal, MD is a member of the following medical societies: American Association for Cancer Research, American Society of Pediatric Hematology/Oncology

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Cameron K Tebbi, MD Director, Children's Cancer Research Group Laboratories

Cameron K Tebbi, MD is a member of the following medical societies: International Society of Pediatric Oncology

Disclosure: Nothing to disclose.

Kathleen M Sakamoto, MD, PhD Shelagh Galligan Professor, Division of Hematology/Oncology, Department of Pediatrics, Stanford University School of Medicine

Kathleen M Sakamoto, MD, PhD is a member of the following medical societies: American Association for Cancer Research, American Society of Hematology, American Society of Pediatric Hematology/Oncology, International Society for Experimental Hematology, Society for Pediatric Research, Western Society for Pediatric Research

Disclosure: Nothing to disclose.

Steven K Bergstrom, MD Department of Pediatrics, Division of Hematology-Oncology, Kaiser Permanente Medical Center of Oakland

Steven K Bergstrom, MD is a member of the following medical societies: Alpha Omega Alpha, Children's Oncology Group, American Society of Clinical Oncology, International Society for Experimental Hematology, American Society of Hematology, American Society of Pediatric Hematology/Oncology

Disclosure: Nothing to disclose.

• Print this section
• Print the entire contents of
• Print the entire contents of article