Pediatric Acute Lymphoblastic Leukemia Questions & Answers

Updated: Jan 03, 2019
  • Author: Vikramjit S Kanwar, MBBS, MBA, MRCP(UK), FAAP; Chief Editor: Jennifer Reikes Willert, MD  more...
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Questions & Answers

Overview

What is the prevalence of pediatric acute lymphoblastic leukemia (ALL)?

What are the signs and symptoms of pediatric acute lymphoblastic leukemia (ALL)?

Which routine lab tests are performed in the workup of pediatric acute lymphoblastic leukemia (ALL)?

Which lab tests are performed to classify pediatric acute lymphoblastic leukemia (ALL) type?

Which imaging studies are performed in the workup of pediatric acute lymphoblastic leukemia (ALL)?

Which procedures are performed in the workup of pediatric acute lymphoblastic leukemia (ALL)?

How is CNS disease categorized in pediatric acute lymphoblastic leukemia (ALL)?

What are the phases of treatment for pediatric acute lymphoblastic leukemia (ALL)?

Which medications are used in the treatment of pediatric acute lymphoblastic leukemia (ALL)?

Which nonpharmacologic therapies are used in the treatment of pediatric acute lymphoblastic leukemia (ALL)?

What is the role of a central venous catheter in the treatment of pediatric acute lymphoblastic leukemia (ALL)?

What is pediatric acute lymphoblastic leukemia (ALL)?

What is the pathophysiology of pediatric acute lymphoblastic leukemia (ALL)?

What is the prevalence of pediatric acute lymphoblastic leukemia (ALL) in the US?

What causes pediatric acute lymphoblastic leukemia (ALL)?

What is the prognosis of pediatric acute lymphoblastic leukemia (ALL)?

What are the acute complications of pediatric acute lymphoblastic leukemia (ALL)?

What are the possible complications of pediatric acute lymphoblastic leukemia (ALL) treatment?

What is included in patient education about pediatric acute lymphoblastic leukemia (ALL)?

Presentation

Which clinical history findings are characteristic of pediatric acute lymphoblastic leukemia (ALL)?

Which physical findings are characteristic of pediatric acute lymphoblastic leukemia (ALL)?

DDX

Which conditions are included in the differential diagnoses of acute lymphoblastic leukemia (ALL)?

What are the differential diagnoses for Pediatric Acute Lymphoblastic Leukemia?

Workup

How is acute lymphoblastic leukemia (ALL) diagnosed?

What is the role of immunophenotyping in the workup of pediatric acute lymphoblastic leukemia (ALL)?

What is the prevalence of genetic alterations in leukemic blasts of pediatric acute lymphoblastic leukemia (ALL)?

Which chromosomal abnormalities are associated with favorable outcomes in pediatric acute lymphoblastic leukemia (ALL)?

Which chromosomal abnormalities are associated with poor outcomes in pediatric acute lymphoblastic leukemia (ALL)?

Which chromosomal abnormalities have uncertain prognostic value in pediatric acute lymphoblastic leukemia (ALL)?

Which chromosomal abnormalities associated with pediatric acute lymphoblastic leukemia (ALL) are not revealed on routine testing?

Which chromosomal abnormalities are found in T-lineage pediatric acute lymphoblastic leukemia (ALL)?

What is the role of minimal residual disease studies in the workup of pediatric acute lymphoblastic leukemia (ALL)?

What is the role of ultrasonography in the workup of pediatric acute lymphoblastic leukemia (ALL)?

What is the role of bone marrow aspiration and biopsy in the workup of pediatric acute lymphoblastic leukemia (ALL)?

Which histologic findings are characteristic of pediatric acute lymphoblastic leukemia (ALL)?

What is the role of lab tests in the workup of pediatric acute lymphoblastic leukemia (ALL)?

Treatment

How is pediatric acute lymphoblastic leukemia (ALL) treated?

How is tumor lysis syndrome treated in pediatric acute lymphoblastic leukemia (ALL)?

What is the role of chemotherapy in the treatment of pediatric acute lymphoblastic leukemia (ALL)?

What is the role of consolidation therapy in the treatment of pediatric acute lymphoblastic leukemia (ALL)?

What is the role of interim maintenance therapy in the treatment of pediatric acute lymphoblastic leukemia (ALL)?

What is the role of delayed intensification therapy in the treatment of pediatric acute lymphoblastic leukemia (ALL)?

What is the role of maintenance therapy in the treatment of pediatric acute lymphoblastic leukemia (ALL)?

What is the duration of chemotherapy for the treatment of pediatric acute lymphoblastic leukemia (ALL)?

How is CNS disease treated in pediatric acute lymphoblastic leukemia (ALL)?

What is the role of cranial irradiation in the treatment of pediatric acute lymphoblastic leukemia (ALL)?

How is high-risk pediatric acute lymphoblastic leukemia (ALL) treated?

How is pediatric acute lymphoblastic leukemia (ALL) treated in patients with Down syndrome?

How is relapsed pediatric acute lymphoblastic leukemia (ALL) treated?

What is the role of blinatumomab (Blincyto) in the treatment of relapsed pediatric acute lymphoblastic leukemia (ALL)?

Which chemotherapy agents are used to treat relapsed pediatric acute lymphoblastic leukemia (ALL)?

When is HSCT indicated in the treatment of pediatric acute lymphoblastic leukemia (ALL)?

How is a second relapse or refractory pediatric acute lymphoblastic leukemia (ALL) treated?

What is the role of HSCT in the treatment of pediatric acute lymphoblastic leukemia (ALL)?

What is the role of molecular targeted therapy in the treatment of pediatric acute lymphoblastic leukemia (ALL)?

What is the role of cellular therapy in the treatment of pediatric acute lymphoblastic leukemia (ALL)?

What is the likely cause of treatment failure in pediatric acute lymphoblastic leukemia (ALL)?

Which specialist consultations are beneficial to patients with pediatric acute lymphoblastic leukemia (ALL)?

What is included in the long-term monitoring of pediatric acute lymphoblastic leukemia (ALL)?

Medications

Which medications are used in the treatment of pediatric acute lymphoblastic leukemia (ALL)?

Which medications in the drug class Antifungals are used in the treatment of Pediatric Acute Lymphoblastic Leukemia?

Which medications in the drug class Corticosteroids are used in the treatment of Pediatric Acute Lymphoblastic Leukemia?

Which medications in the drug class Antimicrobials are used in the treatment of Pediatric Acute Lymphoblastic Leukemia?

Which medications in the drug class CAR T-Cell Therapies are used in the treatment of Pediatric Acute Lymphoblastic Leukemia?

Which medications in the drug class Antineoplastics, Tyrosine Kinase Inhibitor are used in the treatment of Pediatric Acute Lymphoblastic Leukemia?

Which medications in the drug class Enzymes, Oncology are used in the treatment of Pediatric Acute Lymphoblastic Leukemia?

Which medications in the drug class Immunomodulators are used in the treatment of Pediatric Acute Lymphoblastic Leukemia?

Which medications in the drug class Antineoplastic Agents are used in the treatment of Pediatric Acute Lymphoblastic Leukemia?