Nasal Polyps Medication

Updated: Jun 16, 2016
  • Author: John E McClay, MD; Chief Editor: Ravindhra G Elluru, MD, PhD  more...
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Medication

Medication Summary

See Medical Care.

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Corticosteroids

Class Summary

Corticosteroids have potent anti-inflammatory action and relieve rhinorrhea, sneezing, itching, and congestion.

Prednisolone (Prelone, Orapred ODT, Pediapred)

Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reducing capillary permeability.

Prednisone (Prednisone Intensol)

May decrease inflammation by reversing increased capillary permeability and suppressing PMN activity.

Dexamethasone (Decadron)

Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reducing capillary permeability.

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Nasal corticosteroids

Class Summary

These agents induce a nonspecific anti-inflammatory response that should theoretically reduce the size of polyps and prevent regrowth when continuously used. Available nasal steroid sprays appear to be similarly effective and relatively safe for both short-term and long-term use.

Mometasone (Nasonex)

Nasal spray; demonstrated no mineralocorticoid, androgenic, antiandrogenic, or estrogenic activity in preclinical trials. Studies concerning bioavailability are established; should be considered first-line when treating pediatric patients. Not systemically absorbed like other nasal steroids (ie, beclomethasone). Studies concerning bioavailability are established; should be considered first-line when treating pediatric patients. Not systemically absorbed like other nasal steroids (ie, beclomethasone).

Fluticasone propionate (Flonase Allergy Relief, Xhance)

Topical nasal steroid. Has extremely potent vasoconstrictive and anti-inflammatory activity. Has a weak hypothalamic-pituitary-adrenocortical axis inhibitory potency when applied topically. Studies concerning bioavailability are established; should be considered first line when treating pediatric patients. Not systemically absorbed like other nasal steroids (ie, beclomethasone).

Nasal drying, epistaxis, and, in long-term use, septal perforation has been reported. Advise patients to administer spray toward lateral nasal wall, avoiding irritation to septum or having drug run down back of pharynx.

Budesonide inhaled (Rhinocort Aqua)

Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability.

Triamcinolone inhaled (Nasacort Allergy Relief, Nasacort HFA)

Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability.

Beclomethasone (Beconase AQ)

Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability. Delivers 42 mcg/actuation.

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Leukotriene Receptor Antagonists

Class Summary

These agents prevent or reverse some of the pathologic features associated with the inflammatory process mediated by leukotrienes.

Montelukast (Singulair)

Potent and selective antagonist of leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1. Prevents or reverses some of the pathologic features associated with the inflammatory process mediated by leukotrienes C4, D4, and E4.

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