Pediatric Subglottic Stenosis Surgery Medication

Updated: Mar 28, 2018
  • Author: John E McClay, MD; Chief Editor: Ravindhra G Elluru, MD, PhD  more...
  • Print
Medication

Medication Summary

No known medical therapy for mature SGS is recognized. If a granular or immature subglottic stenosis (SGS) is noted (see image below), treatment of the inflammatory process with oral or inhaled steroids sometimes can decrease the severity of disease. Findings from animal studies have shown that treatment with antibiotics and steroids can help improve an immature or granular SGS; however, the optimal treatment duration is unknown.

An intraoperative view of granular subglottic sten An intraoperative view of granular subglottic stenosis in a 3-month-old infant who was born premature, weighing 800 g. The area is still granular following cricoid split. This patient required tracheotomy and eventual reconstruction at age 3 years. True vocal cords are shown in the foreground (slightly blurry).
Next:

Corticosteroids

Class Summary

These strong anti-inflammatory agents also have profound metabolic and immunosuppressive effects.

Prednisolone elixir (Orapred, PediaPred, Prelone)

Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reducing capillary permeability. Orapred is said to be more palatable than Prelone. Orapred and Prelone liquid preparations contain 15 mg/5 mL prednisolone. Orapred is also available as PO disintegrating tabs. PediaPred contains 5 mg/5 mL.

Dexamethasone (Decadron)

For various allergic and inflammatory diseases. Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reducing capillary permeability.

Previous
Next:

Antibiotics

Class Summary

Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of the clinical setting. Antibiotic selection should be guided by blood culture sensitivity whenever feasible.

Amoxicillin (Amoxil, Trimox)

Interferes with synthesis of cell wall mucopeptides during active multiplication resulting in bactericidal activity against susceptible bacteria.

Cefprozil (Cefzil)

Binds to one or more of the penicillin-binding proteins, which, in turn, inhibits cell wall synthesis and results in bactericidal activity.

Previous