Cyclosporiasis Medication

Updated: Nov 10, 2022
  • Author: Shipra Gupta, MD; Chief Editor: Russell W Steele, MD  more...
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Medication Summary

Trimethoprim-sulfamethoxazole (TMP-SMZ) has proven effective in managing cyclosporiasis in immunocompetent and immunocompromised hosts. [31] TMP-SMZ administration can reduce shedding of oocysts to 1.3 days (from 9 d) and stops diarrhea within 2 days.

An immunocompromised host requires oral antibiotic therapy for longer periods, followed by prophylaxis to prevent recurrence. Ciprofloxacin is an alternative treatment for those who cannot tolerate sulfa-containing medications. [32] . Treatment with nitazoxanide [33] has also been used with success.



Class Summary

These agents are used to treat infection. The combination product containing TMP-SMZ is considered the DOC for managing cyclosporiasis.

Trimethoprim and sulfamethoxazole (Bactrim, Septra, Cotrim)

The only antibiotic that has been shown effective for treating cyclosporiasis. Inhibits bacterial growth by inhibiting synthesis of dihydrofolic acid.