Increase in Reported cases of Cyclospora cayetanensis Infection, United States, Summer 2017. CDC Health Alert Network. Available at https://emergency.cdc.gov/han/han00405.asp. August 07, 2017; Accessed: August 8, 2017.
Mannheimer SB, Soave R. Protozoal infections in patients with AIDS. Cryptosporidiosis, isosporiasis, cyclosporiasis, and microsporidiosis. Infect Dis Clin North Am. 1994 Jun. 8(2):483-98. [Medline].
Murray P, Rosenthal K, Pfaller M. Intestinal and Urogenital protozoa. Medical Microbiology. 7th edition. 2013. 745-758.
Huang P, Weber JT, Sosin DM, Griffin PM, Long EG, Murphy JJ, et al. The first reported outbreak of diarrheal illness associated with Cyclospora in the United States. Ann Intern Med. 1995 Sep 15. 123(6):409-14. [Medline].
Carter RJ, Guido F, Jacquette G, Rapoport M. Outbreak of cyclosporiasis at a country club -- New York, 1995. : 45th Annual Epidemic Intelligence Service (EIS) Conference. Atlanta, Georgia: US Department of Health and Human Services, Public Health Service April 1996:58;
Herwaldt BL, Ackers ML. An outbreak in 1996 of cyclosporiasis associated with imported raspberries. The Cyclospora Working Group. N Engl J Med. 1997 May 29. 336(22):1548-56. [Medline].
Ho AY, Lopez AS, Eberhart MG, et al. Outbreak of cyclosporiasis associated with imported raspberries, Philadelphia, pennsylvania, 2000. Emerg Infect Dis. 2002 Aug. 8(8):783-8. [Medline]. [Full Text].
CDC. From the Centers for Disease Control and Prevention. Outbreaks of cyclosporiasis--United States, 1997. JAMA. 1997 Jun 11. 277(22):1754. [Medline].
CDC. From the Centers for Disease Control and Prevention. Update: outbreaks of cyclosporiasis--1997. JAMA. 1997 Jul 9. 278(2):108. [Medline].
CDC. From the Centers for Disease Control and Prevention. Update: outbreaks of cyclosporiasis--United States, 1997. JAMA. 1997 Jun 18. 277(23):1838. [Medline].
CDC. From the Centers for Disease Control. Outbreak of cyclosporiasis-- Northern Virginia-Washington, DC-Baltimore, Maryland, metropolitan area, 1997. JAMA. 1997 Aug 20. 278(7):538-9. [Medline].
Hoang LM, Fyfe M, Ong C, et al. Outbreak of cyclosporiasis in British Columbia associated with imported Thai basil. Epidemiol Infect. 2005 Feb. 133(1):23-7. [Medline].
Heilpern KL, Wald M. Update on emerging infections: news from the Centers for Disease Control and Prevention. Outbreak of cyclosporiasis associated with snow peas--Pennsylvania, 2004. Ann Emerg Med. 2005 May. 45(5):529-31. [Medline].
Centers for Disease Control and Prevention (CDC). outbreaks of cyclosporiasis--United States, June-August 2013. MMWR Morb Mortal Wkly Rep. 2013 Nov 1. 62(43):862. [Medline].
Chacin-Bonilla L. Epidemiology of Cyclospora cayetanensis: A review focusing in endemic areas. Acta Trop. 2010 Sep. 115(3):181-93. [Medline].
Samie A, Guerrant RL, Barrett L, Bessong PO, Igumbor EO, Obi CL. Prevalence of intestinal parasitic and bacterial pathogens in diarrhoeal and non-diarroeal human stools from Vhembe district, South Africa. J Health Popul Nutr. 2009 Dec. 27(6):739-45. [Medline]. [Full Text].
Blans MC, Ridwan BU, Verweij JJ, et al. Cyclosporiasis outbreak, Indonesia. Emerg Infect Dis. 2005 Sep. 11(9):1453-5. [Medline].
Iqbal J, Hira PR, Al-Ali F, Khalid N. Cyclospora cayetanensis: first report of imported and autochthonous infections in Kuwait. J Infect Dev Ctries. 2011 May 28. 5(5):383-90. [Medline].
Zhou Y, Lv B, Wang Q, Wang R, Jian F, Zhang L, et al. Prevalence and molecular characterization of Cyclospora cayetanensis, Henan, China. Emerg Infect Dis. 2011 Oct. 17(10):1887-90. [Medline]. [Full Text].
Sifuentes-Osornio J, Porras-Cortés G, Bendall RP, Morales-Villarreal F, Reyes-Terán G, Ruiz-Palacios GM. Cyclospora cayetanensis infection in patients with and without AIDS: biliary disease as another clinical manifestation. Clin Infect Dis. 1995 Nov. 21(5):1092-7. [Medline].
Zar FA, El-Bayoumi E, Yungbluth MM. Histologic proof of acalculous cholecystitis due to Cyclospora cayetanensis. Clin Infect Dis. 2001 Dec 15. 33(12):E140-1. [Medline].
de Górgolas M, Fortés J, Fernández Guerrero ML. Cyclospora cayetanensis Cholecystitis in a patient with AIDS. Ann Intern Med. 2001 Jan 16. 134(2):166. [Medline].
Richardson RF Jr, Remler BF, Katirji B, Murad MH. Guillain-Barré syndrome after Cyclospora infection. Muscle Nerve. 1998 May. 21(5):669-71. [Medline].
Connor BA, Johnson EJ, Soave R. Reiter syndrome following protracted symptoms of Cyclospora infection. Emerg Infect Dis. 2001 May-Jun. 7(3):453-4. [Medline]. [Full Text].
Stark D, Barratt JL, van Hal S, Marriott D, Harkness J, Ellis JT. Clinical significance of enteric protozoa in the immunosuppressed human population. Clin Microbiol Rev. 2009 Oct. 22(4):634-50. [Medline]. [Full Text].
Visvesvara GS, Moura H, Kovacs-Nace E, Wallace S, Eberhard ML. Uniform staining of Cyclospora oocysts in fecal smears by a modified safranin technique with microwave heating. J Clin Microbiol. 1997 Mar. 35(3):730-3. [Medline]. [Full Text].
McHardy IH, Wu M, Shimizu-Cohen R, Couturier MR, Humphries RM. Detection of intestinal protozoa in the clinical laboratory. J Clin Microbiol. 2014 Mar. 52(3):712-20. [Medline]. [Full Text].
Bourée P, Lancon A, Bisaro F, Bonnot G. Six human cyclosporiasis: with general review. J Egypt Soc Parasitol. 2007 Aug. 37(2):349-60. [Medline].
Verdier RI, Fitzgerald DW, Johnson WD Jr, Pape JW. Trimethoprim-sulfamethoxazole compared with ciprofloxacin for treatment and prophylaxis of Isospora belli and Cyclospora cayetanensis infection in HIV-infected patients. A randomized, controlled trial. Ann Intern Med. 2000 Jun 6. 132(11):885-8. [Medline].
Diaz E, Mondragon J, Ramirez E, Bernal R. Epidemiology and control of intestinal parasites with nitazoxanide in children in Mexico. Am J Trop Med Hyg. 2003 Apr. 68(4):384-5. [Medline].
Aksoy U, Akisu C, Sahin S, et al. First reported waterborne outbreak of cryptosporidiosis with Cyclospora co-infection in Turkey. Euro Surveill. 2007. 12(2):E070215.4. [Medline].
American Academy of Pediatrics. Cyclosporiasis. Red Book: 2009 Report of the Committee on Infectious Diseases. 28th. Elk Grove Village, IL: American Academy of Pediatrics; 2009. 274-5.
Arora DR, Arora B. AIDS-associated parasitic diarrhoea. Indian J Med Microbiol. 2009 Jul-Sep. 27(3):185-90. [Medline].
Atkins JT, Cleary TG. Cryptosporidiosis, Cyclospora infection, isosporiasis, and microsporidiosis. Textbook of Pediatric Infectious Diseases. 2004. 2687-707.
Bouree P, Lancon A, Bisaro F, Bonnot G. Six human cyclosporiasis: with general review. J Egypt Soc Parasitol. 2007 Aug. 37(2):349-60. [Medline].
CDC. Outbreak of cyclosporiasis associated with snow peas--Pennsylvania, 2004. MMWR Morb Mortal Wkly Rep. 2004 Sep 24. 53(37):876-8. [Medline]. [Full Text].
Cegielski JP, Ortega YR, McKee S, et al. Cryptosporidium, enterocytozoon, and cyclospora infections in pediatric and adult patients with diarrhea in Tanzania. Clin Infect Dis. 1999 Feb. 28(2):314-21. [Medline].
Chacin-Bonilla L. Transmission of Cyclospora cayetanensis infection: a review focusing on soil-borne cyclosporiasis. Trans R Soc Trop Med Hyg. 2008 Mar. 102(3):215-6. [Medline].
Chiodini PL. New diagnostics in parasitology. Infect Dis Clin North Am. 2005 Mar. 19(1):267-70. [Medline].
Connor BA, Johnson EJ, Soave R. Reiter syndrome following protracted symptoms of Cyclospora infection. Emerg Infect Dis. 2001 May-Jun. 7(3):453-4. [Medline]. [Full Text].
Connor BA, Reidy J, Soave R. Cyclosporiasis: clinical and histopathologic correlates. Clin Infect Dis. 1999 Jun. 28(6):1216-22. [Medline].
Diaz E, Mondragon J, Ramirez E, Bernal R. Epidemiology and control of intestinal parasites with nitazoxanide in children in Mexico. Am J Trop Med Hyg. 2003 Apr. 68(4):384-5. [Medline]. [Full Text].
Dixon BR, Bussey JM, Parrington LJ, Parenteau M. Detection of Cyclospora cayetanensis oocysts in human fecal specimens by flow cytometry. J Clin Microbiol. 2005 May. 43(5):2375-9. [Medline]. [Full Text].
Doller PC, Dietrich K, Filipp N, et al. Cyclosporiasis outbreak in Germany associated with the consumption of salad. Emerg Infect Dis. 2002 Sep. 8(9):992-4. [Medline]. [Full Text].
Eberhard ML, Arrowood MJ. Cyclospora spp. Curr Opin Infect Dis. 2002 Oct. 15(5):519-22. [Medline].
Erickson MC, Ortega YR. Inactivation of protozoan parasites in food, water, and environmental systems. J Food Prot. 2006 Nov. 69(11):2786-808. [Medline].
Farthing MJ. Treatment options for the eradication of intestinal protozoa. Nat Clin Pract Gastroenterol Hepatol. 2006 Aug. 3(8):436-45. [Medline].
Fitzgerald DW, Pape JW. Cyclosporiasis. Curr Treatment Options Infect Dis. 2001. 3:345-9.
Fletcher SM, Stark D, Harkness J, Ellis J. Enteric protozoa in the developed world: a public health perspective. Clin Microbiol Rev. 2012 Jul. 25(3):420-49. [Medline].
Flynn PM. Isospora and Cyclospora species. Principles and Practice of Pediatric Infectious Diseases. 2003. 1280-1.
Fox LM, Saravolatz LD. Nitazoxanide: a new thiazolide antiparasitic agent. Clin Infect Dis. 2005 Apr 15. 40(8):1173-80. [Medline].
Gilles HM, Hoffman PS. Treatment of intestinal parasitic infections: a review of nitazoxanide. Trends Parasitol. 2002 Mar. 18(3):95-7. [Medline].
Hall RL, Jones JL, Herwaldt BL. Surveillance for laboratory-confirmed sporadic cases of cyclosporiasis--United States, 1997-2008. MMWR Surveill Summ. 2011 Apr 8. 60(2):1-11. [Medline].
Hall RL, Jones JL, Hurd S, Smith G, Mahon BE, Herwaldt BL. Population-based active surveillance for Cyclospora infection--United States, Foodborne Diseases Active Surveillance Network (FoodNet), 1997-2009. Clin Infect Dis. 2012 Jun. 54 Suppl 5:S411-7. [Medline].
Harp JA. Parasitic infections of the gastrointestinal tract. Curr Opin Gastroenterol. 2003 Jan. 19(1):31-6. [Medline].
Harrington BJ. Microscopy of 4 pathogenic enteric protozoan parasites: a review. Lab Med. April, 2008. 39(4):231-8. [Full Text].
Herwaldt BL. Cyclospora cayetanensis: a review, focusing on the outbreaks of cyclosporiasis in the 1990s. Clin Infect Dis. 2000 Oct. 31(4):1040-57. [Medline].
Hussein EM. Molecular identification of Cycospora spp. using multiplex PCR from diarrheic children compared to others conventional methods. J Egypt Soc Parasitol. 2007 Aug. 37(2):585-98. [Medline].
Hussein EM, El-Moamly AA, Dawoud HA, Fahmy H, El-Shal HE, Sabek NA. Real-time PCR and flow cytometry in detection of Cyclospora oocysts in fecal samples of symptomatic and asymptomatic pediatrics patients. J Egypt Soc Parasitol. 2007 Apr. 37(1):151-70. [Medline].
Idris NS, Dwipoerwantoro PG, Kurniawan A, Said M. Intestinal parasitic infection of immunocompromised children with diarrhoea: clinical profile and therapeutic response. J Infect Dev Ctries. 2010 Jun 3. 4(5):309-17. [Medline].
Karanis P, Kourenti C, Smith H. Waterborne transmission of protozoan parasites: a worldwide review of outbreaks and lessons learnt. J Water Health. 2007 Mar. 5(1):1-38. [Medline].
Kozak GK, MacDonald D, Landry L, Farber JM. Foodborne outbreaks in Canada linked to produce: 2001 through 2009. J Food Prot. 2013 Jan. 76(1):173-83. [Medline].
Kulkarni SV, Kairon R, Sane SS, Padmawar PS, Kale VA, Thakar MR, et al. Opportunistic parasitic infections in HIV/AIDS patients presenting with diarrhoea by the level of immunesuppression. Indian J Med Res. 2009 Jul. 130(1):63-6. [Medline].
Lalonde LF, Gajadhar AA. Detection and differentiation of coccidian oocysts by real-time PCR and melting curve analysis. J Parasitol. 2011 Aug. 97(4):725-30. [Medline].
Lalonde LF, Gajadhar AA. Highly sensitive and specific PCR assay for reliable detection of Cyclospora cayetanensis oocysts. Appl Environ Microbiol. 2008 Jul. 74(14):4354-8. [Medline].
Lee MB. Everyday and exotic foodborne parasites. Can J Infect Dis. 2000 May. 11(3):155-8. [Medline].
Lewthwaite P, Gill GV, Hart CA, Beeching NJ. Gastrointestinal parasites in the immunocompromised. Curr Opin Infect Dis. 2005 Oct. 18(5):427-35. [Medline].
Lopez AS, Dodson DR, Arrowood MJ, et al. Outbreak of cyclosporiasis associated with basil in Missouri in 1999. Clin Infect Dis. 2001 Apr 1. 32(7):1010-7. [Medline].
Nimri LF. Cyclospora cayetanensis and other intestinal parasites associated with diarrhea in a rural area of Jordan. Int Microbiol. 2003 Jun. 6(2):131-5. [Medline].
Nundy S, Gilman RH, Xiao L, Cabrera L, Cama R, Ortega YR. Wealth and its associations with enteric parasitic infections in a low-income community in peru: use of principal component analysis. Am J Trop Med Hyg. 2011 Jan. 84(1):38-42. [Medline].
Ochoa TJ, Salazar-Lindo E, Cleary TG. Management of children with infection-associated persistent diarrhea. Semin Pediatr Infect Dis. 2004 Oct. 15(4):229-36. [Medline].
Ortega YR, Nagle R, Gilman RH, et al. Pathologic and clinical findings in patients with cyclosporiasis and a description of intracellular parasite life-cycle stages. J Infect Dis. 1997 Dec. 176(6):1584-9. [Medline].
Ortega YR, Sanchez R. Update on Cyclospora cayetanensis, a food-borne and waterborne parasite. Clin Microbiol Rev. 2010 Jan. 23(1):218-34. [Medline]. [Full Text].
Pape JW, Verdier RI, Boncy M, et al. Cyclospora infection in adults infected with HIV. Clinical manifestations, treatment, and prophylaxis. Ann Intern Med. 1994 Nov 1. 121(9):654-7. [Medline]. [Full Text].
Paschke C, Apelt N, Fleischmann E, Perona P, Walentiny C, Löscher T, et al. Controlled study on enteropathogens in travellers returning from the tropics with and without diarrhoea. Clin Microbiol Infect. 2011 Aug. 17(8):1194-200. [Medline].
Pearson RD. Nitazoxanide As Treatment of Intestinal Parasites in Children. Curr Infect Dis Rep. 2004 Feb. 6(1):25-26. [Medline].
Pierce KK, Kirkpatrick BD. Update on human infections caused by intestinal protozoa. Curr Opin Gastroenterol. 2009 Jan. 25(1):12-7. [Medline].
Puente S, Morente A, Garcia-Benayas T, et al. Cyclosporiasis: a point source outbreak acquired in Guatemala. J Travel Med. 2006 Nov-Dec. 13(6):334-7. [Medline].
Shah L, Macdougall L, Ellis A, Ong C, Shyng S, Leblanc L. Challenges of investigating community outbreaks of cyclosporiasis, British Columbia, Canada. Emerg Infect Dis. 2009 Aug. 15(8):1286-8. [Medline]. [Full Text].
Soave R, Herwaldt BL, Relman DA. Cyclospora. Infect Dis Clin North Am. 1998 Mar. 12(1):1-12. [Medline].
Steiner T, Pape J, Guerrant R. Intestinal coccidial infections. Guerrant RL, Walker DH, Weller PF, eds. Tropical Infectious Diseases: Principles, Pathogens, and Practice. Churchill Livingstone; 1999. 721-35.
Suh KN, Keystone JS. Antibiotics for Travelers: What's Good and What's Not. Curr Infect Dis Rep. 2004 Feb. 6(1):13-21. [Medline].
Sun T. Current topics in protozoal diseases [published erratum appears in Am J Clin Pathol 1994 Nov;102(5):708]. Am J Clin Pathol. 1994 Jul. 102(1):16-29. [Medline].
Torres-Slimming PA, Mundaca CC, Moran M, et al. Outbreak of cyclosporiasis at a naval base in Lima, Peru. Am J Trop Med Hyg. 2006 Sep. 75(3):546-8. [Medline].
Tuli L, Singh DK, Gulati AK, Sundar S, Mohapatra TM. A multiattribute utility evaluation of different methods for the detection of enteric protozoa causing diarrhea in AIDS patients. BMC Microbiol. 2010 Jan 15. 10:11. [Medline]. [Full Text].
Valdez LM, Gotuzzo E, DuPont HL. Gastrointestinal symptoms. Guerrant RL, Walker DH, Weller PF, eds. Tropical Infectious Diseases: Principles, Pathogens, and Practice. Churchill Livingstone; 1999. 1367-79.
van Lieshout L, Verweij JJ. Newer diagnostic approaches to intestinal protozoa. Curr Opin Infect Dis. 2010 Oct. 23(5):488-93. [Medline].
Verweij JJ, Blange RA, Templeton K, et al. Simultaneous detection of Entamoeba histolytica, Giardia lamblia, and Cryptosporidium parvum in fecal samples by using multiplex real-time PCR. J Clin Microbiol. 2004 Mar. 42(3):1220-3. [Medline]. [Full Text].
Wiesner J, Reichenberg A, Heinrich S, Schlitzer M, Jomaa H. The plastid-like organelle of apicomplexan parasites as drug target. Curr Pharm Des. 2008. 14(9):855-71. [Medline].
Wilson ME. Diarrhea in nontravelers: risk and etiology. Clin Infect Dis. 2005 Dec 1. 41 Suppl 8:S541-6. [Medline].
Wittner M, Tanowitz HB, Weiss LM. Parasitic infections in AIDS patients. Cryptosporidiosis, isosporiasis, microsporidiosis, cyclosporiasis. Infect Dis Clin North Am. 1993 Sep. 7(3):569-86. [Medline].
Zar FA, El-Bayoumi E, Yungbluth MM. Histologic Proof of Acalculous Cholecystitis Due to Cyclospora cayetanensis. Clin Infect Dis. 2001 Dec 15. 33(12):E140-1. [Medline].
Zimmer SM, Schuetz AN, Franco-Paredes C. Efficacy of nitazoxanide for cyclosporiasis in patients with sulfa allergy. Clin Infect Dis. 2007 Feb 1. 44(3):466-7. [Medline].