Dracunculiasis Medication

Updated: Oct 14, 2023
  • Author: Vinod K Dhawan, MD, FACP, FRCPC, FIDSA; Chief Editor: Russell W Steele, MD  more...
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Antiparasitic agents

Class Summary

These agents are used to speed the pace of worm extraction.

Metronidazole (Flagyl, Protostat)

DOC as therapy adjunctive to extraction. Active against various anaerobic bacteria and protozoa. Intermediate-metabolized compounds formed bind DNA and inhibit protein synthesis, causing cell death.

Thiabendazole (Mintezol)

Acceptable for use in adults only.

Inhibits helminth-specific mitochondrial fumarate reductase; alleviates symptoms of trichinosis during invasive phase.